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Therefore, there is an urgent need for large-scale, methodologically rigorous epidemiological studies to elucidate the potential role of methylation alterations in the development of various cancers and their impact on early detection in clinical samples such as blood, urine, sputum, feces, and tissues

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[DOI] [PMC free article] [PubMed] [Google Scholar] 157.Menichetti A., Mavridi-Printezi A., Mordini D., Montalti M