As clinical experience with these drugs accumulated, their capacity to produce significant weight loss became widely known, and off-label use for obesity and weight management grew substantially
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Moreover, CNS GIPR KO and mGIPR-Ab/GLP-1 treatment of wild-type mice both result in reduced activity in pathways associated with immune function, particularly neutrophil degranulation, suggesting that decreased CNS GIPR signalling might reduce obesity-associated inflammation 47,48,49
A single cause for dementia, for example, which could be targeted for prevention and treatment, has long eluded researchers