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Nat Rev Nephrol

Although weight loss is a well-documented side effect of topiramate, it is licensed in the UK solely for epilepsy and migraine prevention, not for weight management

Studies suggest potential benefits for liver health , with improvements in non-alcoholic fatty liver disease markers

Other suggested mediating pathways by which semaglutide modifies immune system activity include reducing the proliferation of inflammatory cells [62], lowering the uptake of activated macrophages in blood vessels (resulting in fewer vascular injuries) [79], and reducing the development of atherosclerotic plaque lesions [66]

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