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The scenario specification was shared with modelling teams to implement in their models

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Intriguingly, in clear opposition to our results, in vitro studies directed to elucidate the mechanics of GSDMD pore formation have suggested that cholesterol may exert an inhibitory effect [58]

This hormonal preservation is especially relevant for individuals with existing endocrine considerations, those prone to stress-related eating, or anyone seeking to avoid the systemic hormonal disruptions that often accompany aggressive fat loss interventions

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