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To compensate, the pancreas increases insulin production, but cannot achieve positive results, and a progressive disorder of lipid and glucose metabolism takes place

Tofogliflozin, a highly selective inhibitor of sglt2 blocks proinflammatory and proapoptotic effects of glucose overload on proximal tubular cells partly by suppressing oxidative stress generation

Insulin plays a crucial role in this process by directly impacting theca cells, increasing androgen secretion, stimulating the release of plasminogen activator inhibitor-1, and inhibiting plasmin production

When inner ear stem cell therapy becomes a reality

Virmani A, Gaetani F, Imam S, Binienda Z, Ali S