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Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt-containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production, and regulation

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(6.1) The most common adverse reactions (incidence 20%) of pemetrexed when administered in combination with pembrolizumab and platinum chemotherapy are fatigue/asthenia, nausea, constipation, diarrhea, decreased appetite, rash, vomiting, cough, dyspnea, and pyrexia

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