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Approximately 85% of all lung cancers are classified as non-small cell lung cancer (NSCLC) [1]

In this review, we summarize the advantages/disadvantages of these therapeutic agents, providing a critical view of whether they could be effective in the human clinic

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Cancer cells utilize glutamine metabolism-related branched pathways involved in the development of drug resistance Glutamine synthetase (GS), an enzyme that functions at the origin of glutamine metabolism, is the sole regulatory factor that governs glutamine synthesis from its fundamental stages, thereby playing a pivotal role in the progression of cancer [213]