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Since the effects of CTSs on leukocytes and red blood cells are mediated by the activation of signal cascades, it is important to design artificial CTSs that can activate signal cascades without toxic Na,K-ATPase inhibition effect

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Cerebral edema resulting from IS exacerbates microcirculatory disruptions by compressing capillaries, underscoring the importance of minimizing microcirculatory disturbances post-ischemia