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Studies have shown that the expression of inflammatory markers such as Tumor Necrosis Factor alpha (TNF-a) and Interleukin-6 (IL-6) significantly diminish when there are high cellular levels of NAD+ and its precursors

Folate can also be synthesized in vivo through the action of gut bacteria in the large intestine by converting p ABA to dihydrofolate (DHF), THF, and finally 5-MTHF and other derivatives [17]