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Discussion The present study demonstrates that Retatrutide, a triple agonist of the GIP, GLP-1, and glucagon receptors, induces profound adipose tissue remodeling and systemic metabolic improvement in diet-induced obese mice

The potential for weight loss is interesting, but I think the most interesting reason to pursue glucagon agonism in a multi-receptor agonist is the possibility that you could alter hepatic liver metabolism and potentially decrease fatty acid accumulation and hypertriglyceridemia.

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758, Fall, 2013