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This cyclization reaction occurs more readily at higher temperatures and creates peptide fragments that have no therapeutic value

Headache can be a sign of hypoglycemia , or low blood sugar, which can be serious for people with type 2 diabetes

The mechanism of action involves stimulating insulin secretion in a glucose-dependent manner, which means insulin release occurs primarily when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia

If side effects become severe or persistent, dosage adjustments or medication changes may be necessary