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Before starting Mounjaro , your healthcare provider should: Review your personal and family medical history , including any history of cancer, particularly thyroid or gastrointestinal malignancies Assess your individual risk factors for colorectal cancer and ensure you are up to date with NHS screening programmes Discuss the evidence-based benefits of tirzepatide for glycaemic control and weight management Explain common adverse effects and serious risks, ensuring informed consent Establish a monitoring plan, including regular follow-up appointments During ongoing treatment , you should: Report any new or persistent symptoms promptly, particularly severe abdominal pain (possible pancreatitis), gallbladder symptoms, or gastrointestinal changes that differ from expected medication side effects Be aware of hypoglycaemia risk, especially if taking insulin or sulfonylureas If you use oral contraceptives, discuss the need for additional contraceptive methods during initiation and dose increases Attend scheduled reviews to assess treatment response and tolerability Maintain participation in age-appropriate cancer screening programmes (bowel, breast, cervical) Discuss any concerns or information you encounter online or in media reports Your healthcare provider can help contextualise emerging research and distinguish between established evidence and speculative concerns