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Additionally, individual differences in how patients respond to GLP-1 therapy may influence side effect profiles

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1921 At the same time, increased body weight is associated with a lowered level of GLP-1 secretion and a diminished incretin effect

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4 This mitigation is envisioned to be from the dual mechanistic mode of action on the central reward pathways and influence on the gut via delayed gastric emptying, leading to enhanced blood alcohol content and a spike in aversive acetaldehyde levels