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In addition, AKR1C3 expression is regulated by insulin [64], suggesting a significant correlation between testosterone and circulating insulin levels in adipose tissue

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In an in vivo imiquimod-induced PsO mouse model, oral administration of amentoflavone at a dosage of 50 mg/kg significantly reduced epidermal thickness from approximately 300 m to 180 m

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According to the American Diabetes Association , both metformin and lifestyle changes can help prevent or delay type 2 diabetes in people with prediabetes but lifestyle changes have the strongest and longest-lasting effect