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Although the data in this study cannot be extrapolated directly to humans, it does shed some light on potentially important physiologic effects of the medication. The decrease in lean mass with GLP-1 use was associated with a lesser decrease in skeletal muscle mass and a greater decrease in the size of metabolically active organs such as the liver

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As IGF-1R mAbs are readily available for human use, these observations warrant further study into potentially harnessing these drugs to target at least some manifestations of aging

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Anthem is confident because of its past success with products like Plecanatide and Vitamin K2, but the risks remain high