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Consistently, our kinetic trapping approach using the Trx1 C35S mutant revealed that well-known redox regulated proteins, such as Prx1, were trapped upon SFN treatment

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This is also why a secretagogue approach is framed as "axis-friendly": because endogenous somatostatin is still in the loop, negative feedback is preserved, which in principle restrains the supraphysiologic IGF-1 spikes seen with exogenous GH

Journal of clinical and diagnostic research: JCDR