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Finally, metformin belongs to biguanide group commonly used in type II diabetes mellitus as it lowers blood glucose level via activation of AMP-activated protein kinase (AMPK)

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Behind this phenomenon is the deep intervention of GLP-1 in the "central plan" of cellular energy metabolism: it activates GLP-1 receptors, reprograms cellular energy distribution pathways, and shifts the body from an "energy wasting" metabolic mode to an "efficient and economical" one, thereby achieving the dual goals of disease treatment and health improvement