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This increase in intestinal gluconeogenesis leads to portal glucose sensing to regulate energy homeostasis and improve insulin sensitivity 58

On the one hand, some beneficial gut metabolites, such as SCFAs, play roles in maintaining the gut barrier, antioxidant defense, and inhibiting fibrosis

In people with diabetes, GLP-1s reduce blood sugar to improve diabetes management with a lower risk of complications

They also didn't eat more when they stopped getting nicotine