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The concentration of Mn-SOD increases as a protective response to inflammation and OS, and down-regulates NF-kappa B, activator protein-1, and MAPK pathways [250]

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In contrast, fetal muscle showed no changes in mitochondrial activity but displayed reduced expression of genes involved in fat metabolism and energy production, suggesting early transcriptional changes that could affect postnatal muscle energy utilization (Safain et al., 2025)