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The effect of GLP-1RA use was compared with three commonly used antihyperglycemics: dipeptidyl peptidase 4 (DPP4) inhibitors, sulfonylureas, and sodium-glucose cotransporter-2 (SGLT2) inhibitors
Experimental and human metabolic literature demonstrates that GH promotes fatty acid mobilization, shifts substrate preference toward fat oxidation, and alters carbohydrate-lipid partitioning during fasting and metabolic stress states, making GH secretagogue systems useful tools for investigating adipose tissue signaling, fuel selection, and the endocrine regulation of energy metabolism [8]
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