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Diabetes Technol Ther 13(11):11451154

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Adoption and Usage Patterns in the United States Rapid Growth in Prescription Rates GLP-1 medication usage has experienced explosive growth in the United States ^18^22

KLOW lacks patent protection and a clear regulatory approval pathway, so pharmaceutical companies have no financial incentive to fund multi-year Phase 3 trials

Conversely, local tissue hypoxia intensifies inflammatory reactions and immune dysfunction, further exacerbating the imbalance between oxygen supply and demand in local areas