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In a randomized controlled trial, treatment with orlistat 120 mg three times daily resulted in a mean BMI reduction of 0.55 kg/m 2 , whereas the placebo group experienced a mean increase of 0.31 kg/m 2 [58]

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No hay suficiente evidencia sobre la seguridad de la L-carnitina en el embarazo y la lactancia, por lo que no se recomienda su uso Personas con bajo IMC, bajo porcentaje de grasa o problemas cardacos: En estos casos, la L-carnitina puede estar contraindicada

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The risk of myopathy may be further increased in those taking nicotinic acid and bile acid sequestrants (e.g., cholestyramine, colestipol) or the anti-lipidemic drug, gemfibrozil (Lopid), and the risk of hepatotoxicity observed with nicotinic acid might be enhanced by drugs like paracetamol, amiodarone (Cordarone), or carbamazepine (Tegretol) (35)