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In a diabetes MRI substudy, liver fat fell up to 47% at 15 mg versus about 11% on insulin. In biopsy-confirmed fatty-liver disease with fibrosis, a large share of participants on 15 mg had disease resolution versus a small share on placebo. These are not microdose data

Most people tolerate B12 supplementation well, even at doses significantly higher than the recommended daily amount

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Clinical study reference Preclinical and clinical studies such as LY3437943 and TRIUMPH-3 demonstrate research applications, allowing investigators to observe peptides in controlled research settings