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doi: 10.1161/01.CIR.94.11.2743

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Clinical research indicates that the most effective daily dosage for NAD+ precursors (such as nicotinamide riboside or nicotinamide mononucleotide) typically falls within the range of 250 milligrams to 500 milligrams per day for most adults, though some studies safely use up to 1,000mg per day for more robust increases in NAD+ levels

What we can do is explain the variables a prescriber weighs, where published ranges come from, and how genetics sits upstream of the whole question