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Clin Cancer Res 2011

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Screening the child with DS for the MTHFR defect is helpful as well because the genetic polymorphism can be passed on to the child, compromising his or her health beyond existing issues from DS

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Intermembrane proteins released from mitochondria through Bax/Bid pores, e.g., apoptosis inducing factor (AIF) and endonuclease G, translocate to the nucleus and cause DNA fragmentation [53]