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Depending on the treatment, this may involve stimulating collagen production, encouraging healthy cell turnover, improving hydration, or lifting away impurities and buildup that dull the complexion

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Quick Reference: Standard Protocol Community-reported protocols most commonly describe 500 mcg once daily for 8 weeks, then 8 weeks off

That distinction matters: an early lab change is not the same thing as the main body-composition endpoint people usually mean when they ask whether tesamorelin is working. When Would Someone Realistically Judge Progress