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E., Lyons, P

Metabolites involved in metabolic plasticity must be able to fluctuate in response to internal or external perturbations

In the study by Fontcuberta-PiSunyer et al., human fibroblasts were directly reprogrammed using adenoviral vectors delivering NEUROG3, PDX1, and MAFA, followed sequentially by PAX4 and NKX2-2

Considering the potential impacts of stress on various aspects of mouse physiology, any mouse subjected to acute stress (sudden heavy drop owing to operational error, and injury owing to injection error) was also excluded