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It belongs to a novel class of agents known as triple receptor agonists , meaning it simultaneously activates three distinct hormone receptors: GLP-1 (glucagon-like peptide-1) which reduces appetite and slows gastric emptying [7] [8] GIP (glucose-dependent insulinotropic polypeptide) which is hypothesised to enhance insulin secretion and may play a role in fat metabolism, though the precise contribution remains under investigation Glucagon receptor which is thought to increase energy expenditure and promote hepatic fat breakdown, though these mechanisms are still being characterised in human studies [9] [10] This triple mechanism distinguishes retatrutide from existing approved agents such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GLP-1/GIP agonist), and is thought to produce more pronounced effects on body weight

Independent tools designed to help you understand GLP-1 compounds, dosing logic, and trial-based data clearly and transparently

doi: 10.1007/s40495-014-0002-x 53 JiangL-LZhouS-JZhangX-MChenH-QLiuW

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