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What makes AOD 9604 interesting is its selectivity

ABSTRACT: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic polypeptide/GLP-1 RAs are common therapies for managing diabetes and obesity, but gastrointestinal (GI) adverse effects (AEs) such as nausea, vomiting, diarrhea, and constipation frequently limit therapy

GLP-1 helps reduce glucagon levels when they are not needed, helping to keep blood sugar steady

However, the choice of next oral agent to add with metformin is unclear

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