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Ferritin below 50 to 70 ng/mL often produces symptoms even without anemia

The angiogenesis hypothesis may provide new insights by suggesting a decline in angiogenic growth factors with age, which in turn leads to a reduction in microcirculation in the body (Ambrose 2016)

A more complete diagnostic workup may then be necessary to identify the causes of lingering symptoms

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Chemical reactions, mechanisms of antioxidant enzyme activity, enzyme-related diseases (cancer, cardiovascular, lung, metabolic, and neurological diseases), and potential therapeutic applications of enzyme mimics and nanozymes are discussed