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[20] The medication may be useful in selected patients with coexisting depression, smoking cessation goals, or alcohol-use concerns, but it is contraindicated in uncontrolled hypertension, seizure disorder, eating disorders such as anorexia nervosa or bulimia nervosa, chronic opioid use, abrupt discontinuation of alcohol or sedatives, use of other bupropion-containing products, and monoamine oxidase inhibitor use within 14 days

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Pregnancy and Breastfeeding: Compounded GLP-1 medications are not recommended during pregnancy or breastfeeding

Participants on 12 mg Retatrutide lost an average of 28.7% of their body weight (approximately 32.3 kg) over 68 weeks