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By integrating plasma EV proteomics with single-cell PBMC transcriptomics, we obtained convergent, orthogonal evidence for L-serine associated remodeling of immune developmental programs and intercellular communication

Future large-scale randomized trials with extended follow-up and standardized respiratory endpoints are warranted to clarify durability and causal mechanisms

Key safety note: Avoid during pregnancy and breastfeeding

This designation supports proper experimental protocols while maintaining compliance with regulatory requirements for research compound distribution and use

They also reduce glucagon release