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In its rejection, the regulator said additional efficacy data are required to support an approval

The most commonly reported adverse effects are gastrointestinal in nature and include: Nausea (particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment when the dose is being gradually increased

The last big factor when it comes to answering that question is your basal metabolic rate