Many studies indicate an association between increased VEGF expression in the brain, brain hypoperfusion, and increased BBB permeability, which increases unwanted angiogenesis, and may favor the occurrence of neurodegenerative diseases (Chen et al
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Electrical stimulation may counter some of the negative effects of implantation, such as it can modulate inflammatory responses [388], but can implantation itself be additive and positively alter gene expression
Aconitase activity To evaluate a functional consequence of oxidative stress, the activity of the redox-sensitive enzyme, aconitase, was measured using the Aconitase Assay Kit (Cayman Chemical, Ann Arbor, MI, USA) following the manufacturer's instructions
Remarkably, 5-cholesten-3-one, derived by oxidation of the 3-hydroxyl group of cholesterol, is not a substrate in spite of a structure of the A and B rings identical to that in 5-AD and 5-PD, in which the double bond isomerization occurs (Figure 2)
