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It reduces the activity of tyrosinase by three different mechanisms: (i) chelation of the copper site by its thiol group, (ii) interfering with the cellular transfer of tyrosinase to premelanosomes which is a prerequisite for melanin synthesis, and (iii) indirectly via its antioxidant effect.[] Glutathione shifts melanogenesis from eumelanin to phaeomelanin synthesis by reactions between thiol groups and dopa-quinone leading to the formation of sulfhydryl-dopa conjugates.[] It has also been found to be scavenger of UV radiation-induced reactive oxygen species generated in epidermal cells.[] METHODS This was a prospective comparative study to assess and compare the therapeutic efficacy of localized TA and glutathione for treatment of facial melasma over a period of 18 months (December 2017 to May 2019) conducted in department of dermatology on OPD basis in a tertiary care center
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It is also fortified in nutritional yeast products and some breakfast cereals
In addition, researchers have developed a multifunctional biomimetic nanoplatform (referred to as HM-BPT), which utilizes pH-sensitive tumor-targeting hybrid membrane-coated manganese oxide nanoparticles for the delivery of the glutaminase inhibitor BPTES
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