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Previous studies have also demonstrated that GLP-1R agonists exendin-4 (Ex4) induced diuresis and natriuresis by increasing GFR and inhibiting the main renal proximal tubule sodium reabsorption in normotensive rats (101, 102)
[7] [8] Authorities in Switzerland have also allowed prescription of the drug for EPP with reimbursement approved by two unnamed insurers [9] Afamelanotide is currently being clinically trialled in the form of a "grain of rice" sized bioabsorbable subcutaneous implant as a potential therapeutic photoprotection inducing agent for a series of light related skin indications as well as a potential dermal repigmentation agent for vitiligo
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