Patients should contact their GP or prescribing clinician if they experience any of the following: Severe or worsening fatigue that: Persists despite implementing lifestyle modifications Progressively worsens rather than improving over time Significantly impairs daily functioning, work performance, or quality of life Is accompanied by weakness, dizziness, or fainting episodes Associated symptoms suggesting potential complications: Severe, persistent abdominal pain, possibly radiating to the back, with or without vomiting (potential signs of pancreatitis requiring urgent medical attention) Pain in the right upper abdomen, fever, or jaundice (potential signs of gallbladder disease) Persistent nausea, vomiting, or diarrhoea leading to dehydration Signs of dehydration: dark urine, dry mouth, reduced urine output, confusion Rapid or irregular heartbeat, chest pain, or shortness of breath Unexplained weight loss exceeding recommended targets (faster than about 0.5-1 kg per week) Mood changes, depression, or anxiety Yellowing of skin or eyes, dark urine, or pale stools (potential liver concerns) For patients with diabetes, particularly those taking insulin or sulfonylureas, symptoms of hypoglycaemia (sweating, shakiness, confusion, irritability) alongside fatigue require prompt attention and potential medication adjustment
Morat X, Lujn R, Lpez-Cano M, Ganda J, Stagljar I, Watanabe M, et al
Nevertheless, oxidative stress is implicated in the pathogenesis of numerous diseases and can inflict damage on diverse cell types and tissues
Los agonistas GLP-1 sintticos han sido modificados qumicamente para resistir la degradacin rpida que sufre la hormona natural, lo que permite administraciones semanales o incluso diarias segn el medicamento especfico
Drugs 2023, 32, 10031008
