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184 Overall, natural and synthetic SIRT1 activators rely on SIRT1s multi-dimensional roles in metabolism, inflammation, and oxidative stress regulation in MASLD, as shown in Table 1

Once-weekly cagrilintide for weight management in adults with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled phase 2 trial

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In this trial, a dose-response curve was demonstrated where the greater the degree of weight loss, the more significant the improvement in histopathology, such that 10% weight loss was associated with an improvement in all features of MASLD, including portal inflammation and fibrosis