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Factors such as: Degree of insulin resistance Presence of other conditions (cardiovascular disease, fatty liver disease, sleep apnoea) Family history of diabetes or obesity Age and menopausal status Previous weight loss attempts and patterns of weight regain Safety considerations and tolerability play an important role

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( NY Post ) GLP-1s are also being studied for perimenopausal symptom relief , including hot flashes and mood swings, and for fatty liver disease , due to their anti-inflammatory and insulin-regulating effects

doi: 10.1016/s0022-510x(98)00095-1