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The structural basis for MC4R-selective agonism has been refined through macrocyclic peptide design: recent work applying Goldilocks-inspired optimization strategies has produced mid-size macrocycles with enhanced selectivity profiles, providing molecular insight into the receptor-ligand interactions that distinguish PT-141 from broader-spectrum melanocortin analogs (PMID: 42340853)

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Granulocyte/macrophage colony-stimulating factor influences angiogenesis by regulating the coordinated expression of VEGF and the Ang/Tie system