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Specifically, an RCT comparing the initial combination of a DPP-4 inhibitor with metformin versus sequential add-on therapy after metformin failure showed that the combination therapy delayed treatment failure without differences in safety or adverse effects [481]

I suspect the guidelines will evolve to become more strict with time

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2 respuestas No es contraindicacion absoluta, sin embrago, los medicamentos para la perdida de peso, tipo Redotex, siempre deben ser manejados por un experto en el tema, el manejo de sobrepeso y obesidad debe ser personalizada segun el paciente y su historial, no es recomemdable automedicarse y combinar medicamentos, el exito del tratamiento siempre depende del apego al manejo indicado por el medico

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