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37,38 In some MDD patients, stress leads to long-term elevated glucocorticoids, resulting in synaptic structural changes and remodeling, and the stress-induced hyperactivity of the HPA axis leads to negative feedback imbalance of the HPA axis, which is also related to depression

Aquat Toxicol 87:139145 Roberts SC, Noyes PD, Gallagher EP, Stapleton HM (2011) Species-specific differences and structureactivity relationships in the debromination of PBDE congeners in three fish species