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Jan 20, 2026 9 min read IN THIS ARTICLE KEY TAKEAWAYS GLP-1 medications can reduce appetite and temporarily lower energy

Exendin-4 significantly increased insulin level and phosphorylation of insulin receptor substrate 1 (IRS-1) in rat hippocampus, and could not change the status of tau phosphorylation without insulin in HT22 neurons, suggesting that insulin is required in reduction of tau hyperphosphorylation by GLP-1R agonists (154)

In March 2025, a major new study was published in the journal Nature Medicine

But always disclose your complete supplement and medication list to your prescribing physician

Keep a detailed health log tracking both your menstrual cycle and semaglutide usage, and discuss any irregularities with your healthcare provider