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ROS are a necessary defense system to combat microbial respiratory infections (Lambeth, 2004), but oxidative stress and the excessive production of ROS by numerous cells including monocytes and macrophages, neutrophils, as well as pulmonary endothelial and epithelial cells play a major role in the development of ARDS and its complications during COVID-19 infections (Meftahi et al., 2021)

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Community-derived FOXO4-DRI daily dosing ladder Week Weeks 1-4 Daily Dose 250 mcg Week Weeks 5-8 Daily Dose 375 mcg Week Weeks 9-12 Daily Dose 500 mcg Week Weeks 13-16 Daily Dose 500 mcg Reported community dosing only

This is common and nothing to be concerned about