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Weight loss under the action of GLP-1RA is not only caused by acting on the hypothalamus or parasympathetic nervous system, thereby inhibiting appetite and delaying gastric emptying, but also by acting on white and brown adipocytes.40 GLP-1RA can promote browning of white adipocytes in mice through fat breakdown and oxidation, significantly reducing fat content.41 Yahui Zhang et al found that GLP-1RA can alleviate hyperinsulinemia and hyperandrogenism in PCOS mice by reducing inflammation of white adipose tissue and stimulating browning of white adipose tissue.42 Xiong et al confirmed that semaglutide modulated the diversity of gut microbiota in PCOS patients.43 Previous clinical trials have shown that both metformin and metformin combined with liraglutide can improve the menstrual cycle, weight, and glucose metabolism in obese PCOS patients

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