Yes, combining B12 therapy with physical therapy and pain management can enhance treatment
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GLP-1RA Reward Behaviour Systematic Review (PubMed, 2024) GLP-1 Receptor Signalling in Reward Circuitry, Dopamine, and Addiction Research A systematic review of GLP-1 receptor agonist effects on reward behaviour published on PubMed following PRISMA guidelines across OVID, PubMed, Scopus, and Google Scholar evaluated the evidence for GLP-1Rs role in reward dysfunction across obesity, type 2 diabetes, and psychiatric conditions
Realworld studies demonstrate high discontinuation rates of GLP1RAs by up to 75% within the first year of use, predominantly driven by side effects 20-22
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