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A combined metabolic and anabolic strategy offers a more complete solution by addressing both sides of the equationfat loss and muscle preservation

Cortisol is a potent catabolic hormone and immunomodulator that alters gene expression in virtually every tissue, so any GH secretagogue that co-elevates cortisol introduces a major confounding variable that requires additional control groups and complicates data interpretation in anabolic or metabolic studies

1992 Feb 15;282 ( Pt 1)(Pt 1):91-7

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Also, its growth hormone-stimulating properties make it unsafe for people with active cancer ,27 and its action on the pituitary gland means its unsuitable for people with a pituitary gland disorder