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As of 2026, updated clinical guidance is increasingly clear that tirzepatide should be considered a long-term or indefinite treatment for most people, not a short course you eventually taper off

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Hyperactivity in the dorsal cochlear nucleus after intense sound exposure and its resemblance to tone-evoked activity: A physiological model for tinnitus

About 3% to 7% of patients treated with tirzepatide and 1% in the placebo group reported injection site reactions