Adding semaglutide to tirzepatide would, in theory, increase total GLP-1 receptor occupancy without adding meaningful GIP activationpotentially increasing side effects without proportional clinical benefit
Wegovy: started at 0.25 mg weekly and escalated every 4 weeks up to 1.7 mg or 2.4 mg weekly maintenance (2.4 mg is the recommended maintenance dose for most indications on the label) (FDA Wegovy label, 2025)
A health warning on repurposed drugs None of the above should be read to suggest and it is not DW's recommendation that anyone use GLP-1 agonists, or any other drug, to treat any "off label"/non-approved condition, without personal, professional medical advice
Mental health: Combats anxiety, depression, and stress
While Mounjaro costs can range from $1,000 to $1,200 monthly, its insurance coverage often aligns with type 2 diabetes needs, necessitating prior authorization processes and specific coverage approvals