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transient impairment of glucose tolerance is possible, particularly in individuals with pre-existing insulin resistance Injection site reactions: Mild and typically localised Contraindications include active malignancy (GH-IGF-1 signalling can promote tumour growth), pituitary-dependent conditions, pregnancy, and active diabetic retinopathy

The research, published in JAMA Psychiatry, provides reassurance that use of GLP1-RAs, such as semaglutide, are not associated with any increased risk of psychiatric adverse events or worsening of depressive symptoms

Piezo1 expression in neutrophils regulates shear-induced NETosis

Most of the samples (11 of 15

Participants receiving 2.4 mg weekly semaglutide lost an average of 15.3% of body weight over 68 weeks, with improvements in blood sugar control and cardiovascular risk factors